Interleucina 17A
| Identificadores | |
| Símbolo | IL17A |
| Símbolos alt. | IL17, CTLA8 |
| Entrez | 3605 |
| HUGO | 5981 |
| OMIM | |
| RefSeq | NP_002181 |
| UniProt | Q16552 |
| Outros datos | |
A interleucina 17A (IL-17A ou IL17A) é unha proteína reguladora do tipo das citocinas que nos humanos etá codificada no xene IL17A do cromosoma 6.[1][2] Foi a primeira interleucina descuberta da familia da IL-17, polo que tamén se lle deu inicialmente o símbolo IL17, e en ratos CTLA8.
A proteína codificada por este xene é unha citocina proinflamatoria producida por células T activadas. Esta citocina regula a actividade do NF-kappaB e as proteína quinases activadas por mitóxeno. Esta citocina pode estimular a expresión de IL6 e da ciclooxixenase 2 (PTGS2/COX-2), e tamén potencia a produción de óxido nítrico (NO). Altos niveis desta citocina están asociados con varias doenzas inflamatorias crónicas como a artrite reumatoide, psoríase e esclerose múltiple.[2]
Notas[editar | editar a fonte]
- ↑ Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P (Jul 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". J Immunol 150 (12): 5445–56. PMID 8390535.
- ↑ 2,0 2,1 "Entrez Gene: IL17A interleukin 17A".
Véxase tamén[editar | editar a fonte]
Outros artigos[editar | editar a fonte]
Bibliografía[editar | editar a fonte]
- Gaffen SL (2005). "Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.". Arthritis Res. Ther. 6 (6): 240–7. PMC 1064872. PMID 15535837. doi:10.1186/ar1444.
- Lubberts E, Koenders MI, van den Berg WB (2006). "The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.". Arthritis Res. Ther. 7 (1): 29–37. PMC 1064899. PMID 15642151. doi:10.1186/ar1478.
- Yao Z, Painter SL, Fanslow WC; et al. (1996). "Human IL-17: a novel cytokine derived from T cells.". J. Immunol. 155 (12): 5483–6. PMID 7499828.
- Fossiez F, Djossou O, Chomarat P; et al. (1996). "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.". J. Exp. Med. 183 (6): 2593–603. PMC 2192621. PMID 8676080. doi:10.1084/jem.183.6.2593.
- Yao Z, Spriggs MK, Derry JM; et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor.". Cytokine 9 (11): 794–800. PMID 9367539. doi:10.1006/cyto.1997.0240.
- Murphy KP, Gagne P, Pazmany C, Moody MD (1998). "Expression of human interleukin-17 in Pichia pastoris: purification and characterization.". Protein Expr. Purif. 12 (2): 208–14. PMID 9518462. doi:10.1006/prep.1997.0832.
- Teunissen MB, Koomen CW, de Waal Malefyt R; et al. (1998). "Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.". J. Invest. Dermatol. 111 (4): 645–9. PMID 9764847. doi:10.1046/j.1523-1747.1998.00347.x.
- Shalom-Barak T, Quach J, Lotz M (1998). "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.". J. Biol. Chem. 273 (42): 27467–73. PMID 9765276. doi:10.1074/jbc.273.42.27467.
- Shin HC, Benbernou N, Fekkar H; et al. (1999). "Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway.". Cytokine 10 (11): 841–50. PMID 9878122. doi:10.1006/cyto.1998.0375.
- Laan M, Cui ZH, Hoshino H; et al. (1999). "Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.". J. Immunol. 162 (4): 2347–52. PMID 9973514.
- Kotake S, Udagawa N, Takahashi N; et al. (1999). "IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.". J. Clin. Invest. 103 (9): 1345–52. PMC 408356. PMID 10225978. doi:10.1172/JCI5703.
- Shin HC, Benbernou N, Esnault S, Guenounou M (1999). "Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.". Cytokine 11 (4): 257–66. PMID 10328864. doi:10.1006/cyto.1998.0433.
- Andoh A, Takaya H, Makino J; et al. (2001). "Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells.". Clin. Exp. Immunol. 125 (1): 56–63. PMC 1906093. PMID 11472426. doi:10.1046/j.1365-2249.2001.01588.x.
- Laan M, Palmberg L, Larsson K, Lindén A (2002). "Free, soluble interleukin-17 protein during severe inflammation in human airways.". Eur. Respir. J. 19 (3): 534–7. PMID 11936535. doi:10.1183/09031936.02.00280902.
- Andoh A, Fujino S, Bamba S; et al. (2002). "IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts.". J. Immunol. 169 (4): 1683–7. PMID 12165487. doi:10.4049/jimmunol.169.4.1683.
- Andoh A, Shimada M, Bamba S; et al. (2002). "Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts.". Biochim. Biophys. Acta 1591 (1-3): 69–74. PMID 12183057. doi:10.1016/S0167-4889(02)00250-1.
- Hsieh HG, Loong CC, Lin CY (2003). "Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells.". Cytokine 19 (4): 159–74. PMID 12297109. doi:10.1006/cyto.2002.1952.
- Aggarwal S, Ghilardi N, Xie MH; et al. (2003). "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.". J. Biol. Chem. 278 (3): 1910–4. PMID 12417590. doi:10.1074/jbc.M207577200.
- Maertzdorf J, Osterhaus AD, Verjans GM (2003). "IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.". J. Immunol. 169 (10): 5897–903. PMID 12421973. doi:10.4049/jimmunol.169.10.5897.
- Este artigo incorpora textos en dominio público da Biblioteca Nacional de Medicina dos Estados Unidos.
