A acuaporina 3 é unha proteína que funciona como canle acuosa que se encontra na membrana plasmática basolateral das células principais do conduto colector e proporciona unha vía para que a auga saia das células.[1] No ril, a AQP3 é regulada pola vasopresina (ADH).[2] Esta proteína é tamén un determinante para o sistema de grupos sanguíneos GIL.[3] Nos humanos está codificada no xeneAQP3 do cromosoma 9.
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