Acuaporina 3
(Redirección desde «AQP3»)
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| PDB | Buscar ortólogos: PDBe, RCSB | ||
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| Nomenclatura | Outros nomes
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| Símbolo | AQP3 (HGNC: 636) | ||
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| Locus | Cr. 9 p13.3 | ||
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A acuaporina 3 é unha proteína que funciona como canle acuosa que se encontra na membrana plasmática basolateral das células principais do conduto colector e proporciona unha vía para que a auga saia das células.[1] No ril, a AQP3 é regulada pola vasopresina (ADH).[2] Esta proteína é tamén un determinante para o sistema de grupos sanguíneos GIL.[3] Nos humanos está codificada no xene AQP3 do cromosoma 9.
O ácido suberoilaniluro hidroxámico (SAHA) (un inhibidor de HDAC) incrementa a expresión de acuaporina 3 en células de pel normal (queratinocitos).[4]
Importancia clínica[editar | editar a fonte]
Os niveis de AQP3 adoitan ser máis baixos na psoríase que cando a pel está sa.[4]
A AQP3 exprésase máis no eccema atópico.[5]
Notas[editar | editar a fonte]
- ↑ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. PMID 9558461. doi:10.1146/annurev.physiol.60.1.199.
- ↑ Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – vía Elsevier.
- ↑ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. PMID 12239222. doi:10.1074/jbc.M208999200.
- ↑ 4,0 4,1 Cancer therapy shows promise for psoriasis treatment
- ↑ Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema.". Allergy 61 (9): 1132–7. PMID 16918518. doi:10.1111/j.1398-9995.2006.01151.x.
Véxase tamén[editar | editar a fonte]
Outros artigos[editar | editar a fonte]
Bibliografía[editar | editar a fonte]
- Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte.". Mol. Biochem. Parasitol. 167 (1): 48–53. PMID 19393693. doi:10.1016/j.molbiopara.2009.04.006.
- Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations.". Transfusion 48 (6): 1164–8. PMID 18435676. doi:10.1111/j.1537-2995.2008.01683.x.
- Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture.". J. Soc. Gynecol. Investig. 13 (3): 181–5. PMID 16638588. doi:10.1016/j.jsgi.2006.02.002.
- Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells.". Respiratory Physiology & Neurobiology 161 (2): 111–8. PMID 18280225. doi:10.1016/j.resp.2007.12.007.
- Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine.". Biochem. Biophys. Res. Commun. 373 (4): 613–7. PMID 18601899. doi:10.1016/j.bbrc.2008.06.086.
- Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.". Biochem. Biophys. Res. Commun. 387 (3): 564–8. PMID 19619514. doi:10.1016/j.bbrc.2009.07.077.
- Bellemère G, Von Stetten O, Oddos T (2008). "Retinoic acid increases aquaporin 3 expression in normal human skin.". J. Invest. Dermatol. 128 (3): 542–8. PMID 17943189. doi:10.1038/sj.jid.5701047.
- Cohly HH, Isokpehi R, Rajnarayanan RV (2008). "Compartmentalization of aquaporins in the human intestine.". Int J Environ Res Public Health 5 (2): 115–9. PMC 2694936. PMID 18678926. doi:10.3390/ijerph5020115.
- Lee TC, Ho IC, Lu WJ, Huang JD (2006). "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line.". J. Biol. Chem. 281 (27): 18401–7. PMID 16672223. doi:10.1074/jbc.M601266200.
- Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing.". J. Mol. Med. 86 (2): 221–31. PMID 17968524. doi:10.1007/s00109-007-0272-4.
- Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009). "The expression of differentiation markers in aquaporin-3 deficient epidermis.". Arch. Dermatol. Res. 301 (3): 245–52. PMC 3582396. PMID 19184071. doi:10.1007/s00403-009-0927-9.
- Wang J, Tanji N, Kikugawa T, et al. (2007). "Expression of aquaporin 3 in the human prostate.". Int. J. Urol. 14 (12): 1088–92; discussion 1092. PMID 18036046. doi:10.1111/j.1442-2042.2007.01901.x.
- Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin.". J. Cell. Biochem. 102 (4): 1051–8. PMID 17471492. doi:10.1002/jcb.21350.
- Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation.". J. Cell. Physiol. 217 (2): 338–49. PMID 18543247. doi:10.1002/jcp.21506.
- Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc.". J. Mol. Histol. 39 (3): 303–9. PMID 18247144. doi:10.1007/s10735-008-9166-1.
- Avril-Delplanque A, Casal I, Castillon N, et al. (2005). "Aquaporin-3 expression in human fetal airway epithelial progenitor cells.". Stem Cells 23 (7): 992–1001. PMID 16043462. doi:10.1634/stemcells.2004-0197.
- Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.". J. Membr. Biol. 208 (1): 55–64. PMID 16596446. doi:10.1007/s00232-005-0819-7.
- Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues.". Hum. Pathol. 38 (1): 171–8. PMID 17056099. doi:10.1016/j.humpath.2006.07.015.
Ligazóns externas[editar | editar a fonte]
- Sistema de grupos sanguíneos GIL en BGMUT Blood Group Antigen Gene Mutation Database no NCBI, NIH
- Localización no xenoma humano de AQP3 e páxina con detalles sobre o xene AQP3 no UCSC Genome Browser.
