Troponina I tipo 1
Troponina I tipo 1 (músculo esquelético, lenta)
| |
| Identificadores | |
| Símbolo | TNNI1 |
| Entrez | 7135 |
| HUGO | 11945 |
| OMIM | |
| RefSeq | NM_003281 |
| UniProt | Q96DT9 |
| Outros datos | |
| Locus | Cr. 1 q31.3 |
A troponina I, músculo esquelético lento ou troponina I tipo 1 (TNNI1) é unha proteína que nos humanos está codificada no xene TNNI1.[1][2][3] É unha das tres isoformas da troponina I; as outras dúas son TNNI2 e TNNI3. Esta isoforma exprésase nos músculos esqueléticos de contracción lenta nos adultos. Únese á actina dos filamentos finos musculares mantendo inhibida a contracción muscular (cando o calcio se une á troponina C esta inhibición desaparece). A troponina é un complexo de tres subunidades: troponina C, I e T.
O seu xene ten 12,5 kb, contén 9 exóns e o seu promotor carece das secuencias típicas TATA ou CCAAT. O promotor está regulado por un amplificador (enhancer) específico do tecido muscular.[2]
Notas[editar | editar a fonte]
- ↑ Wade R, Eddy R, Shows TB, Kedes L (Aug 1990). "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I". Genomics 7 (3): 346–57. PMID 2365354. doi:10.1016/0888-7543(90)90168-T.
- ↑ 2,0 2,1 Corin SJ, Juhasz O, Zhu L, Conley P, Kedes L, Wade R (May 1994). "Structure and expression of the human slow twitch skeletal muscle troponin I gene". J Biol Chem 269 (14): 10651–9. PMID 8144655.
- ↑ "Entrez Gene: TNNI1 troponin I type 1 (skeletal, slow)".
Véxase tamén[editar | editar a fonte]
Bibliografía[editar | editar a fonte]
- Hunkeler NM, Kullman J, Murphy AM (1991). "Troponin I isoform expression in human heart.". Circ. Res. 69 (5): 1409–14. PMID 1934363. doi:10.1161/01.res.69.5.1409.
- Bhavsar PK, Dhoot GK, Cumming DV; et al. (1992). "Developmental expression of troponin I isoforms in fetal human heart.". FEBS Lett. 292 (1-2): 5–8. PMID 1959627. doi:10.1016/0014-5793(91)80820-S.
- Suzuki H, Kawarabayasi Y, Kondo J; et al. (1990). "Structure and regulation of rat long-chain acyl-CoA synthetase.". J. Biol. Chem. 265 (15): 8681–5. PMID 2341402.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Jha PK, Leavis PC, Sarkar S (1997). "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system.". Biochemistry 35 (51): 16573–80. PMID 8987992. doi:10.1021/bi9622433.
- Tiso N, Rampoldi L, Pallavicini A; et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.". Biochem. Biophys. Res. Commun. 230 (2): 347–50. PMID 9016781. doi:10.1006/bbrc.1996.5958.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Jha PK, Sarkar S (1998). "A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I.". Biochemistry 37 (35): 12253–60. PMID 9724539. doi:10.1021/bi980025z.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948. PMID 11076863. doi:10.1101/gr.143000.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072. PMID 11230166. doi:10.1101/gr.GR1547R.
- Lindhout DA, Li MX, Schieve D, Sykes BD (2002). "Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C.". Biochemistry 41 (23): 7267–74. PMID 12044157. doi:10.1021/bi020100c.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Westfall MV, Borton AR (2003). "Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes.". J. Biol. Chem. 278 (36): 33694–700. PMID 12815045. doi:10.1074/jbc.M305404200.
- Polly P, Haddadi LM, Issa LL; et al. (2003). "hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer.". J. Biol. Chem. 278 (38): 36603–10. PMID 12857748. doi:10.1074/jbc.M212814200.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Thijssen VL, Ausma J, Gorza L; et al. (2005). "Troponin I isoform expression in human and experimental atrial fibrillation.". Circulation 110 (7): 770–5. PMID 15289369. doi:10.1161/01.CIR.0000138849.03311.C6.
- Brobbey A, Ravakhah K (2004). "Elevated serum cardiac troponin I level in a patient after a grand mal seizure and with no evidence of cardiac disease.". Am. J. Med. Sci. 328 (3): 189–91. PMID 15367881. doi:10.1097/00000441-200409000-00012.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.