STX4

STX4
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Nomenclatura	Outros nomes STX4, STX4A, p35-2, sintaxina 4 ;
Identificadores; externos	OMIM: 186591 ; MGI: 893577 ; HomoloGene: 105435 ; EBI: STX4; GeneCards: Xene STX4; UniProt: STX4;
Locus	Cr. 16 p11.2
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Padrón de expresión de ARNm
	Máis información
Ortólogos
Especies
Humano	Rato
Entrez
6810	20909
Ensembl
Véxase HS	Véxase MM
UniProt
Q12846	P70452
RefSeq; (ARNm)
NM_001272095	NM_009294
RefSeq; (proteína) NCBI
NP_001259024	NP_033320
Localización (UCSC)
Cr. 16:; 31.03 – 31.04 Mb	Cr. 7:; 127.42 – 127.45 Mb
PubMed (Busca)
6810 ;	20909

A sintaxina-4 é unha proteína do grupo das sintaxinas que nos humanos está codificada no xene STX4 do cromosoma 16.^[1]^[2]^[3]

Interaccións[editar | editar a fonte]

A STX4 presenta interaccións con:

Xelsolina,^[4]
NAPA,^[5]
RAB4A,^[6]
SNAP-25,^[7]^[8]^[9]^[10]
SNAP23,^[8]^[10]^[11]^[12]^[13]^[14]^[15]^[16]
STXBP1,^[7]^[17]
STXBP5,^[18]
STXBP3,^[17]^[18]
TXLNB,^[19]
VAMP2,^[9]^[14]^[20]^[21]
VAMP3,^[5]^[11]^[14]^[22] e
Proteína de membrana asociada a vesículas 8.^[14]^[22]

Notas[editar | editar a fonte]

↑ Li H, Hodge DR, Pei GK, Seth A (xuño de 1994). "Isolation and sequence analysis of the human syntaxin-encoding gene". Gene 143 (2): 303–4. PMID 8206394. doi:10.1016/0378-1119(94)90117-1.
↑ Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T (febreiro de 2006). "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Molecular Biology of the Cell 17 (2): 977–89. PMC 1356605. PMID 16339081. doi:10.1091/mbc.E05-05-0462.
↑ "Entrez Gene: STX4 Syntaxin 4".
↑ Kalwat MA, Wiseman DA, Luo W, Wang Z, Thurmond DC (xaneiro de 2012). "Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis". Molecular Endocrinology (Baltimore, Md.) 26 (1): 128–41. PMC 3248323. PMID 22108804. doi:10.1210/me.2011-1112.
↑ ^5,0 ^5,1 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (outubro de 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. doi:10.1038/nature04209.
↑ Li L, Omata W, Kojima I, Shibata H (febreiro de 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry 276 (7): 5265–73. PMID 11063739. doi:10.1074/jbc.M003883200.
↑ ^7,0 ^7,1 Hata Y, Südhof TC (xuño de 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry 270 (22): 13022–8. PMID 7768895. doi:10.1074/jbc.270.22.13022.
↑ ^8,0 ^8,1 Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry 271 (23): 13300–3. PMID 8663154. doi:10.1074/jbc.271.23.13300.
↑ ^9,0 ^9,1 Reed GL, Houng AK, Fitzgerald ML (abril de 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441. doi:10.1182/blood.V93.8.2617.
↑ ^10,0 ^10,1 Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (decembro de 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry 273 (51): 34171–9. PMID 9852078. doi:10.1074/jbc.273.51.34171.
↑ ^11,0 ^11,1 Imai A, Nashida T, Yoshie S, Shimomura H (agosto de 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology 48 (8): 597–604. PMID 12828989. doi:10.1016/s0003-9969(03)00116-x.
↑ Li G, Alexander EA, Schwartz JH (maio de 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry 278 (22): 19791–7. PMID 12651853. doi:10.1074/jbc.M212250200.
↑ Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (maio de 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications 234 (1): 257–62. PMID 9168999. doi:10.1006/bbrc.1997.6560.
↑ ^14,0 ^14,1 ^14,2 ^14,3 Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (xuño de 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology 164 (11): 5850–7. PMID 10820264. doi:10.4049/jimmunol.164.11.5850.
↑ Kawanishi M, Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M (marzo de 2000). "Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2". The Journal of Biological Chemistry 275 (11): 8240–7. PMID 10713150. doi:10.1074/jbc.275.11.8240.
↑ Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ (abril de 2003). "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". The Journal of Biological Chemistry 278 (15): 13462–7. PMID 12556468. doi:10.1074/jbc.M210483200.
↑ ^17,0 ^17,1 Schraw TD, Lemons PP, Dean WL, Whiteheart SW (agosto de 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal 374 (Pt 1): 207–17. PMC 1223584. PMID 12773094. doi:10.1042/BJ20030610.
↑ ^18,0 ^18,1 Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (setembro de 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry 278 (37): 35093–101. PMID 12832401. doi:10.1074/jbc.M304261200.
↑ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (xullo de 2004). "Identification and characterization of taxilin isoforms". Biochemical and Biophysical Research Communications 319 (3): 936–43. PMID 15184072. doi:10.1016/j.bbrc.2004.05.073.
↑ Mollinedo F, Martín-Martín B, Calafat J, Nabokina SM, Lazo PA (xaneiro de 2003). "Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils". Journal of Immunology 170 (2): 1034–42. PMID 12517971. doi:10.4049/jimmunol.170.2.1034.
↑ Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW (agosto de 1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". The Biochemical Journal 317 (3): 945–54. PMC 1217577. PMID 8760387. doi:10.1042/bj3170945.
↑ ^22,0 ^22,1 Polgár J, Chung SH, Reed GL (agosto de 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. PMID 12130530. doi:10.1182/blood.v100.3.1081.

Véxase tamén[editar | editar a fonte]

Bibliografía[editar | editar a fonte]

Bennett MK, García-Arrarás JE, Elferink LA, Peterson K, Fleming AM, Hazuka CD, Scheller RH (setembro de 1993). "The syntaxin family of vesicular transport receptors". Cell 74 (5): 863–73. PMID 7690687. doi:10.1016/0092-8674(93)90466-4.
Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (xuño de 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. PMID 7791877. doi:10.1038/375594a0.
Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW (agosto de 1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". The Biochemical Journal 317 (Pt 3): 945–54. PMC 1217577. PMID 8760387. doi:10.1042/bj3170945.
Mandon B, Chou CL, Nielsen S, Knepper MA (agosto de 1996). "Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking". The Journal of Clinical Investigation 98 (4): 906–13. PMC 507504. PMID 8770861. doi:10.1172/JCI118873.
Timmers KI, Clark AE, Omatsu-Kanbe M, Whiteheart SW, Bennett MK, Holman GD, Cushman SW (decembro de 1996). "Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein". The Biochemical Journal 320 (Pt 2): 429–36. PMC 1217948. PMID 8973549. doi:10.1042/bj3200429.
Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE (marzo de 1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". The Journal of Biological Chemistry 272 (10): 6179–86. PMID 9045631. doi:10.1074/jbc.272.10.6179.
Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (maio de 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications 234 (1): 257–62. PMID 9168999. doi:10.1006/bbrc.1997.6560.
Inoue T, Nielsen S, Mandon B, Terris J, Kishore BK, Knepper MA (novembro de 1998). "SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles". The American Journal of Physiology 275 (5 Pt 2): F752–60. PMID 9815132. doi:10.1152/ajprenal.1998.275.5.F752.
Reed GL, Houng AK, Fitzgerald ML (abril de 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441. doi:10.1182/blood.V93.8.2617.
Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu LJ, Noda Y, Saltiel AR, Pessin JE (xuño de 1999). "Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes". Molecular Cell 3 (6): 751–60. PMID 10394363. doi:10.1016/S1097-2765(01)80007-1.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (xullo de 1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Molecular Biology of the Cell 10 (7): 2285–95. PMC 25443. PMID 10397765. doi:10.1091/mbc.10.7.2285.
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (novembro de 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer 83 (4): 456–64. PMID 10508479. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5.
Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (xuño de 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology 164 (11): 5850–7. PMID 10820264. doi:10.4049/jimmunol.164.11.5850.
Li L, Omata W, Kojima I, Shibata H (febreiro de 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry 276 (7): 5265–73. PMID 11063739. doi:10.1074/jbc.M003883200.
Logan MR, Lacy P, Bablitz B, Moqbel R (febreiro de 2002). "Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis". The Journal of Allergy and Clinical Immunology 109 (2): 299–306. PMID 11842301. doi:10.1067/mai.2002.121453.
Dent J, Kato K, Peng XR, Martinez C, Cattaneo M, Poujol C, Nurden P, Nurden A, Trimble WS, Ware J (marzo de 2002). "A prototypic platelet septin and its participation in secretion". Proceedings of the National Academy of Sciences of the United States of America 99 (5): 3064–9. PMC 122473. PMID 11880646. doi:10.1073/pnas.052715199.
Perskvist N, Roberg K, Kulyté A, Stendahl O (marzo de 2002). "Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils". Journal of Cell Science 115 (Pt 6): 1321–30. PMID 11884531. doi:10.1242/jcs.115.6.1321.
Polgár J, Chung SH, Reed GL (Aug 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. PMID 12130530. doi:10.1182/blood.V100.3.1081.
Scales SJ, Hesser BA, Masuda ES, Scheller RH (agosto de 2002). "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly". The Journal of Biological Chemistry 277 (31): 28271–9. PMID 12145319. doi:10.1074/jbc.M204929200.

Ligazóns externas[editar | editar a fonte]

Relación de toda a información estrutural dispoñible en PDB para UniProt: P70452 (Mouse Syntaxin-4) en PDBe-KB.

Este artigo sobre bioloxía é, polo de agora, só un bosquexo. Traballa nel para axudar a contribuír a que a Galipedia mellore e medre.
Existen igualmente outros artigos relacionados con este tema nos que tamén podes contribuír.

[pmid8206394-1] Li H, Hodge DR, Pei GK, Seth A (xuño de 1994). "Isolation and sequence analysis of the human syntaxin-encoding gene". Gene 143 (2): 303–4. PMID 8206394. doi:10.1016/0378-1119(94)90117-1.

[pmid16339081-2] Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T (febreiro de 2006). "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Molecular Biology of the Cell 17 (2): 977–89. PMC 1356605. PMID 16339081. doi:10.1091/mbc.E05-05-0462.

[3] "Entrez Gene: STX4 Syntaxin 4".

[pmid22108804-4] Kalwat MA, Wiseman DA, Luo W, Wang Z, Thurmond DC (xaneiro de 2012). "Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis". Molecular Endocrinology (Baltimore, Md.) 26 (1): 128–41. PMC 3248323. PMID 22108804. doi:10.1210/me.2011-1112.

[pmid16189514-5] 5,0 ^5,1 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (outubro de 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. doi:10.1038/nature04209.

[pmid11063739-6] Li L, Omata W, Kojima I, Shibata H (febreiro de 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry 276 (7): 5265–73. PMID 11063739. doi:10.1074/jbc.M003883200.

[pmid7768895-7] 7,0 ^7,1 Hata Y, Südhof TC (xuño de 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry 270 (22): 13022–8. PMID 7768895. doi:10.1074/jbc.270.22.13022.

[pmid8663154-8] 8,0 ^8,1 Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry 271 (23): 13300–3. PMID 8663154. doi:10.1074/jbc.271.23.13300.

[pmid10194441-9] 9,0 ^9,1 Reed GL, Houng AK, Fitzgerald ML (abril de 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441. doi:10.1182/blood.V93.8.2617.

[pmid9852078-10] 10,0 ^10,1 Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (decembro de 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry 273 (51): 34171–9. PMID 9852078. doi:10.1074/jbc.273.51.34171.

[pmid12828989-11] 11,0 ^11,1 Imai A, Nashida T, Yoshie S, Shimomura H (agosto de 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology 48 (8): 597–604. PMID 12828989. doi:10.1016/s0003-9969(03)00116-x.

[pmid12651853-12] Li G, Alexander EA, Schwartz JH (maio de 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry 278 (22): 19791–7. PMID 12651853. doi:10.1074/jbc.M212250200.

[pmid9168999-13] Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (maio de 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications 234 (1): 257–62. PMID 9168999. doi:10.1006/bbrc.1997.6560.

[pmid10820264-14] 14,0 ^14,1 ^14,2 ^14,3 Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (xuño de 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology 164 (11): 5850–7. PMID 10820264. doi:10.4049/jimmunol.164.11.5850.

[pmid10713150-15] Kawanishi M, Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M (marzo de 2000). "Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2". The Journal of Biological Chemistry 275 (11): 8240–7. PMID 10713150. doi:10.1074/jbc.275.11.8240.

[pmid12556468-16] Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ (abril de 2003). "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". The Journal of Biological Chemistry 278 (15): 13462–7. PMID 12556468. doi:10.1074/jbc.M210483200.

[pmid12773094-17] 17,0 ^17,1 Schraw TD, Lemons PP, Dean WL, Whiteheart SW (agosto de 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal 374 (Pt 1): 207–17. PMC 1223584. PMID 12773094. doi:10.1042/BJ20030610.

[pmid12832401-18] 18,0 ^18,1 Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (setembro de 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry 278 (37): 35093–101. PMID 12832401. doi:10.1074/jbc.M304261200.

[pmid15184072-19] Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (xullo de 2004). "Identification and characterization of taxilin isoforms". Biochemical and Biophysical Research Communications 319 (3): 936–43. PMID 15184072. doi:10.1016/j.bbrc.2004.05.073.

[pmid12517971-20] Mollinedo F, Martín-Martín B, Calafat J, Nabokina SM, Lazo PA (xaneiro de 2003). "Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils". Journal of Immunology 170 (2): 1034–42. PMID 12517971. doi:10.4049/jimmunol.170.2.1034.

[pmid8760387-21] Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW (agosto de 1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". The Biochemical Journal 317 (3): 945–54. PMC 1217577. PMID 8760387. doi:10.1042/bj3170945.

[pmid12130530-22] 22,0 ^22,1 Polgár J, Chung SH, Reed GL (agosto de 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. PMID 12130530. doi:10.1182/blood.v100.3.1081.

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