Precursor da alfa-1-microglobulina/bikunina

AMBP
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1BIK , 3QKG , 4ES7 , 4U30 ;
Identificadores
Nomenclatura	Outros nomes AMBP, A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI, precursor da alfa-1-microglobulina/bikunina ;
Símbolos	AMBP (HGNC: 453) AMBP, A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI
Identificadores; externos	OMIM: 176870 ; MGI: 88002 ; HomoloGene: 1234 ; EBI: AMBP; GeneCards: Xene AMBP; UniProt: AMBP;
Locus	Cr. 9 q32
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Padrón de expresión de ARNm
	Máis información
Ortólogos
Especies
Humano	Rato
Entrez
259	11699
Ensembl
Véxase HS	Véxase MM
UniProt
P02760	Q07456
RefSeq; (ARNm)
NM_001633	NM_007443
RefSeq; (proteína) NCBI
NP_001624	NP_031469
Localización (UCSC)
Cr. 9:; 114.06 – 114.08 Mb	Cr. 4:; 63.06 – 63.07 Mb
PubMed (Busca)
259 ;	11699

O precursor da alfa-1-microglobulina/bikunina ou proteína AMBP é unha proteína que nos humanos está codificada no xene AMBP do cromosoma 9. É unha proteína precursora que se divide dando lugar á alfa-1-microglobulina (proteína da superfamilia da lipocalina) e a bikunina^[1] (da superfamilia ITI).^[2]^[3]^[4]^[5]

Interaccións

O precursor da alfa-1-microglobulina/bikunina presenta interaccións con CD79A.^[6]^[7]

Notas

↑ Erik Fries, Anna M Blom. Bikunin — not just a plasma proteinase inhibitor. The International Journal of Biochemistry & Cell Biology. Volume 32. Issue 2, 2000. Pages 125-137. ISSN 1357-2725 . https://doi.org/10.1016/S1357-2725(99)00125-9. (https://www.sciencedirect.com/science/article/pii/S1357272599001259)
↑ OMIM AMBP
↑ Vetr H, Gebhard W (1990). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler 371 (12): 1185–96. PMID 1708673. doi:10.1515/bchm3.1990.371.2.1185.
↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics 14 (1): 83–8. PMID 1385302. doi:10.1016/S0888-7543(05)80287-3.
↑ "Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor".
↑ Grubb AO, López C, Tejler L, Mendez E (decembro de 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. 258 (23): 14698–707. PMID 6196366. doi:10.1016/S0021-9258(17)43919-6.
↑ Berggård T, Thelin N, Falkenberg C, Enghild JJ, Akerström B (maio de 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. 245 (3): 676–83. PMID 9183005. doi:10.1111/j.1432-1033.1997.00676.x.

Véxase tamén

Outros artigos

Alfa-1-microglobulina

Bibliografía

Akerström B, Lögdberg L, Berggård T, Osmark P, Lindqvist A (2000). "alpha(1)-Microglobulin: a yellow-brown lipocalin". Biochim. Biophys. Acta 1482 (1–2): 172–84. PMID 11058759. doi:10.1016/S0167-4838(00)00157-6.
Kobayashi H, Suzuki M, Hirashima Y, Terao T (2003). "The protease inhibitor bikunin, a novel anti-metastatic agent". Biol. Chem. 384 (5): 749–54. PMID 12817471. doi:10.1515/BC.2003.083.
Ekström B, Berggård I (1977). "Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties". J. Biol. Chem. 252 (22): 8048–57. PMID 72071. doi:10.1016/S0021-9258(17)40934-3.
Escribano J, Lopex-Otin C, Hjerpe A, Grubb A, Mendez E (1990). "Location and characterization of the three carbohydrate prosthetic groups of human protein HC". FEBS Lett. 266 (1–2): 167–70. PMID 1694784. doi:10.1016/0014-5793(90)81531-R.
Diarra-Mehrpour M, Bourguignon J, Sesboüé R, Salier JP, Léveillard T, Martin JP (1990). "Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene". Eur. J. Biochem. 191 (1): 131–9. PMID 1696200. doi:10.1111/j.1432-1033.1990.tb19102.x.
Gebhard W, Schreitmüller T, Vetr H, Wachter E, Hochstrasser K (1990). "Complementary DNA and deduced amino acid sequences of procine alpha 1-microglobulin and bikunin". FEBS Lett. 269 (1): 32–6. PMID 1696914. doi:10.1016/0014-5793(90)81112-2.
Falkenberg C, Grubb A, Akerström B (1990). "Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue". J. Biol. Chem. 265 (27): 16150–7. PMID 1697852. doi:10.1016/S0021-9258(17)46201-6.
Nazimova SV, Akulenko IV, Zaĭtseva IV, Zaraĭskiĭ EI, Posiseeva LV (1990). "[Immunoenzyme analysis of placenta-specific alpha(1)-microglobulin in the blood serum in normal and pathological pregnancy]". Akush Ginekol (Mosk) (7): 70–2. PMID 1700638.
Escribano J, Grubb A, Calero M, Méndez E (1991). "The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC". J. Biol. Chem. 266 (24): 15758–63. PMID 1714898. doi:10.1016/S0021-9258(18)98474-7.
Enghild JJ, Salvesen G, Hefta SA, Thøgersen IB, Rutherfurd S, Pizzo SV (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem. 266 (2): 747–51. PMID 1898736. doi:10.1016/S0021-9258(17)35235-3.
Reisinger P, Hochstrasser K, Albrecht GJ, Lempart K, Salier JP (1985). "Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase". Biol. Chem. Hoppe-Seyler 366 (5): 479–83. PMID 2408638. doi:10.1515/bchm3.1985.366.1.479.
Bourguignon J, Diarra-Mehrpour M, Sesboüé R, Frain M, Sala-Trepat JM, Martin JP, Salier JP (1985). "Human inter-alpha-trypsin-inhibitor: characterization and partial nucleotide sequencing of a light chain-encoding cDNA". Biochem. Biophys. Res. Commun. 131 (3): 1146–53. PMID 2413856. doi:10.1016/0006-291X(85)90210-4.
Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F (1986). "Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1472–5. Bibcode:1986PNAS...83.1472M. PMC 323098. PMID 2419908. doi:10.1073/pnas.83.5.1472.
Traboni C, Cortese R (1986). "Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin)". Nucleic Acids Res. 14 (15): 6340. PMC 311643. PMID 2428011. doi:10.1093/nar/14.15.6340.
Kaumeyer JF, Polazzi JO, Kotick MP (1986). "The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC)". Nucleic Acids Res. 14 (20): 7839–50. PMC 311818. PMID 2430261. doi:10.1093/nar/14.20.7839.
Zaraĭskiĭ EI, Nazimova SV, Olefirenko GA, Pchelkina ZM, Petrunin DD, Tatarinov IuS, Fuks BB (1990). "[Immunoenzyme analysis of placenta-specific alpha 1-microglobulin in the serum of blood donors]". Vopr. Med. Khim. 35 (5): 130–2. PMID 2482577.
Schreitmüller T, Hochstrasser K, Reisinger PW, Wachter E, Gebhard W (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler 368 (8): 963–70. PMID 3663330. doi:10.1515/bchm3.1987.368.2.963.
Morii M, Travis J (1985). "The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein". Biol. Chem. Hoppe-Seyler 366 (1): 19–21. PMID 3890890. doi:10.1515/bchm3.1985.366.1.19.

Ligazóns externas

A base de datos on line MEROPS para peptidases e os seus inhibidores: LI02-001^{[Ligazón morta]}

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[1] Erik Fries, Anna M Blom. Bikunin — not just a plasma proteinase inhibitor. The International Journal of Biochemistry & Cell Biology. Volume 32. Issue 2, 2000. Pages 125-137. ISSN 1357-2725 . https://doi.org/10.1016/S1357-2725(99)00125-9. (https://www.sciencedirect.com/science/article/pii/S1357272599001259)

[2] OMIM AMBP

[pmid1708673-3] Vetr H, Gebhard W (1990). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler 371 (12): 1185–96. PMID 1708673. doi:10.1515/bchm3.1990.371.2.1185.

[pmid1385302-4] Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics 14 (1): 83–8. PMID 1385302. doi:10.1016/S0888-7543(05)80287-3.

[entrez-5] "Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor".

[pmid6196366-6] Grubb AO, López C, Tejler L, Mendez E (decembro de 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. 258 (23): 14698–707. PMID 6196366. doi:10.1016/S0021-9258(17)43919-6.

[pmid9183005-7] Berggård T, Thelin N, Falkenberg C, Enghild JJ, Akerström B (maio de 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. 245 (3): 676–83. PMID 9183005. doi:10.1111/j.1432-1033.1997.00676.x.

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