Factor de crecemento de hepatocitos: Diferenzas entre revisións

Explorar o historial de forma interactiva

← Edición máis vella Edición máis nova →

Contido eliminado Contido engadido

En liña

Revisión como estaba o 5 de maio de 2018 ás 11:12


PDB 1bht
Factor de crecemento de hepatocitos
Identificadores
Símbolo	HGF
Símbolos alt.	DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor
Entrez	3082
OMIM	142409
RefSeq	NP_000592
UniProt	P14210
Outros datos
Locus	Cr. 7 7q21.11:(81.7 – 81.77 Mb)

O factor de crecemento de hepatocitos (HGF) (ou factor de dispersión, en inglés scatter factor ou SF) é un factor de crecemento celular parácrino, de motilidade e morfoxénico. É segregado polas células mesenquimais e ten como diana e actúa principalmente sobre células epiteliais e endoteliais, pero tamén actúa sobre as células proxenitoras hematopoéticas e células T. Ten un importante papel no desenvolvemento de órganos embrionarios, especificamente na mioxénese, na rexeneración de órganos adultos e na curación de feridas.^[1]

Función

Notas

↑ Gallagher, J.T., Lyon, M. (2000). "Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens". En Iozzo, M, V. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. pp. 27–59.

Véxase tamén

Outros artigos

Bibliografía

Michalopoulos GK, Zarnegar R (1992). "Hepatocyte Growth Factor". Hepatology 15 (1): 149–54. doi:10.1002/hep.1840150125.
Nakamura T (1992). "Structure and function of hepatocyte growth factor". Progress in Growth Factor Research 3 (1): 67–85. PMID 1838014. doi:10.1016/0955-2235(91)90014-U.
Ware LB, Matthay MA (May 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology 282 (5): L924–40. PMID 11943656. doi:10.1152/ajplung.00439.2001.
Funakoshi H, Nakamura T (January 2003). "Hepatocyte growth factor: from diagnosis to clinical applications". Clinica Chimica Acta; International Journal of Clinical Chemistry 327 (1–2): 1–23. PMID 12482615. doi:10.1016/S0009-8981(02)00302-9.
Skibinski G (2004). "The role of hepatocyte growth factor/c-met interactions in the immune system". Archivum Immunologiae Et Therapiae Experimentalis 51 (5): 277–82. PMID 14626426.
Kalluri R, Neilson EG (December 2003). "Epithelial-mesenchymal transition and its implications for fibrosis". The Journal of Clinical Investigation 112 (12): 1776–84. PMC 297008. PMID 14679171. doi:10.1172/JCI20530.
Hurle RA, Davies G, Parr C, Mason MD, Jenkins SA, Kynaston HG, Jiang WG (October 2005). "Hepatocyte growth factor/scatter factor and prostate cancer: a review". Histology and Histopathology 20 (4): 1339–49. PMID 16136515. doi:10.14670/HH-20.1339.
Kemp LE, Mulloy B, Gherardi E (June 2006). "Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors". Biochemical Society Transactions 34 (Pt 3): 414–7. PMID 16709175. doi:10.1042/BST0340414.

Ligazóns externas

Hepatocyte growth factor Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA.
Hepatocyte growth factor en Atlas of Genetics and Oncology
Páxina da UCSD Signaling Gateway Molecule en HGF

[1] Gallagher, J.T., Lyon, M. (2000). "Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens". En Iozzo, M, V. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. pp. 27–59.

[1]

@@ Liña 79: / Liña 79: @@
 * {{MeshName|Hepatocyte+growth+factor}}
 * [http://atlasgeneticsoncology.org/Genes/HGFID385ch7q21.html Hepatocyte growth factor] en [[Atlas of Genetics and Cytogenetics in Oncology and Haematology|Atlas of Genetics and Oncology]]
-* Páxinaa da UCSD Signaling Gateway Molecule en [http://www.signaling-gateway.org/molecule/query;jsessionid=91a63736ae2def075573341606d54c19bbd937b3321a22673dceb6cfb49c4f1f?afcsid=A004032 HGF]
+* Páxina da UCSD Signaling Gateway Molecule en [http://www.signaling-gateway.org/molecule/query;jsessionid=91a63736ae2def075573341606d54c19bbd937b3321a22673dceb6cfb49c4f1f?afcsid=A004032 HGF]
 {{PDB Gallery|geneid=3082}}