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Rabia[editar | editar a fonte]

Lenda "Hidrofobia", caricatura de Pasteur na revista londiniense Vanity Fair, xaneiro de 1887.[1]

Pasteur fabricou a primeira vacina contra a rabia cultivando o virus en coellos e debilitándoo despois secando o tecido nervioso afectado.[2][3] The rabies vaccine was initially created by Emile Roux, a French doctor and a colleague of Pasteur, who had produced a killed vaccine using this method.[4] The vaccine had been tested in 50 dogs before its first human trial.[5][6] This vaccine was used on 9-year-old Joseph Meister, on 6 July 1885, after the boy was badly mauled by a rabid dog.[7][3] This was done at some personal risk for Pasteur, since he was not a licensed physician and could have faced prosecution for treating the boy.[8] After consulting with physicians, he decided to go ahead with the treatment.[9] Over 11 days, Meister received 13 inoculations, each inoculation using viruses that had been weakened for a shorter period of time.[10] Three months later he examined Meister and found that he was in good health.[9][11] Pasteur was hailed as a hero and the legal matter was not pursued.[8] Analysis of his laboratory notebooks shows that Pasteur had treated two people before his vaccination of Meister. One survived but may not actually have had rabies, and the other died of rabies.[10][12] Pasteur began treatment of Jean-Baptiste Jupille on 20 October 1885, and the treatment was successful.[10] Later in 1885, people, including four children from the United States, went to Pasteur's laboratory to be inoculated.[9] In 1886, he treated 350 people, of which only one developed rabies.[10] The treatment's success laid the foundations for the manufacture of many other vaccines. The first of the Pasteur Institutes was also built on the basis of this achievement.[7]

In The Story of San Michele, Axel Munthe writes of some risks Pasteur undertook in the rabies vaccine research:[13] Modelo:Blockquote

Because of his study in germs, Pasteur encouraged doctors to sanitize their hands and equipment before surgery. Prior to this, few doctors or their assistants practiced these procedures.[14][15] Ignaz Semmelweis and Joseph Lister had earlier practiced hand sanitizing in medical contexts in the 1860s.[16][17]

  1. ↑ "959.025 | Collections Online". collections.thackraymuseum.co.uk. Consultado o 5 de xullo do 2024. 
  2. ↑ Erro no código da cita: Etiqueta <ref> non válida; non se forneceu texto para as referencias de nome Schwartz
  3. ↑ 3,0 3,1 Wood, Margaret E. (3 de xuño de 2016). "Biting Back". Chemical Heritage Magazine 28 (2). p. 7. Arquivado dende o orixinal o 21 March 2018. Consultado o 5 de xullo do 2024.  Parámetro descoñecido |url-status= ignorado (Axuda)
  4. ↑ Erro no código da cita: Etiqueta <ref> non válida; non se forneceu texto para as referencias de nome Ligon
  5. ↑ Hook, Sue Vander (2011). Louis Pasteur: Groundbreaking Chemist & Biologist. ABDO. p. 8. ISBN 978-1-61714-783-8.  Parámetro descoñecido |url-access= ignorado (Axuda)
  6. ↑ Corole D, Bos (2014). "Louis Pasteur and the Rabies Virus – Louis Pasteur Meets Joseph Meister". Awesome Stories. Arquivado dende o orixinal o 29 November 2014. Consultado o 22 November 2014.  Parámetro descoñecido |url-status= ignorado (Axuda)
  7. ↑ 7,0 7,1 Erro no código da cita: Etiqueta <ref> non válida; non se forneceu texto para as referencias de nome cohn
  8. ↑ 8,0 8,1 Erro no código da cita: Etiqueta <ref> non válida; non se forneceu texto para as referencias de nome van
  9. ↑ 9,0 9,1 9,2 Erro no código da cita: Etiqueta <ref> non válida; non se forneceu texto para as referencias de nome Wasik
  10. ↑ 10,0 10,1 10,2 10,3 Erro no código da cita: Etiqueta <ref> non válida; non se forneceu texto para as referencias de nome Jackson
  11. ↑ Trueman C. "Louis Pasteur". HistoryLearningSite.co.uk. Arquivado dende o orixinal o 20 May 2015. Consultado o 3 July 2013.  Parámetro descoñecido |url-status= ignorado (Axuda)
  12. ↑ Artenstein, Andrew W., ed. (2009). Vaccines: A Biography. Springer. p. 79. ISBN 978-1-4419-1108-7. 
  13. ↑ Munthe, Axel (2010) [First published 1929]. "V: Patients". The Story of San Michele. Hachette UK. ISBN 978-1-84854-526-7. 
  14. ↑ Melin, Maxwell David (2016). "The Industrial Revolution and the Advent of Modern Surgery". Intersect: The Stanford Journal of Science, Technology, and Society (en inglés) 9 (2): online (1–13). Arquivado dende o orixinal o 25 August 2021. Consultado o 25 August 2021.  Parámetro descoñecido |url-status= ignorado (Axuda)
  15. ↑ Magerl, Mary Ann (2008). "Operating Room Sanitation: Routine Cleaning Versus Terminal Cleaning". Perioperative Nursing Clinics (en inglés) 3 (2): 143–148. doi:10.1016/j.cpen.2008.01.007. Arquivado dende o orixinal o 26 May 2021. Consultado o 25 August 2021.  Parámetro descoñecido |url-status= ignorado (Axuda)
  16. ↑ Vermeil, T.; Peters, A.; Kilpatrick, C.; Pires, D.; Allegranzi, B.; Pittet, D. (2019). "Hand hygiene in hospitals: anatomy of a revolution". Journal of Hospital Infection (en inglés) 101 (4): 383–392. PMID 30237118. doi:10.1016/j.jhin.2018.09.003. Arquivado dende o orixinal o 19 February 2022. Consultado o 25 August 2021.  Parámetro descoñecido |url-status= ignorado (Axuda); Parámetro descoñecido |s2cid= ignorado (Axuda)
  17. ↑ Larson, E (1989). "Innovations in health care: antisepsis as a case study.". American Journal of Public Health (en inglés) 79 (1): 92–99. PMC 1349481. PMID 2642372. doi:10.2105/AJPH.79.1.92. 
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