CD7
CD7
| |
| Identificadores | |
| Símbolo | CD7 |
| Símbolos alt. | GP40; LEU-9; TP41; Tp40 |
| Entrez | 924 |
| HUGO | 1695 |
| OMIM | |
| RefSeq | NM_006137 |
| UniProt | P09564 |
| Outros datos | |
| Locus | Cr. 17 q25 |
O CD7 (cluster de diferenciación 7) é unha proteína humana da superficie celular codificada no xene CD7 do cromosoma 17, que se encontra nos timocitos e células T maduras.[1] Este xene codifica unha proteína transmembrana de 40 kDa que é un membro da superfamilia das inmunoglobulinas. O CD7 xoga un papel esencial nas interaccións das células T e tamén nas interaccións célula T/célula B durante o desenvolvemento linfoide temperán.[1]
Interaccións
[editar | editar a fonte]O CD7 interacciona con PIK3R1.[2][3]
Importancia clínica
[editar | editar a fonte]O CD7 pode ser expresado de forma anormal en certos tipos de anemia (anemia RAEB) e iso pode significar un peor prognóstico. Emprégase como marcador da leucemia linfática aguda de células T e para as leucemias de células nai pluripotenciais.[1][4]
Notas
[editar | editar a fonte]- ↑ 1,0 1,1 1,2 "Entrez Gene: CD7 CD7 molecule".
- ↑ Lee, D M; Patel D D, Pendergast A M, Haynes B F (1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. (ENGLAND) 8 (8): 1195–203. ISSN 0953-8178. PMID 8918688. doi:10.1093/intimm/8.8.1195.
- ↑ Subrahmanyam, Gosukonda; Rudd Christopher E, Schneider Helga (2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. (Germany) 33 (1): 46–52. ISSN 0014-2980. PMID 12594831. doi:10.1002/immu.200390006.
- ↑ Janeway, Jr; et al. (2000). Inmunobiología. Masson, SA. ISBN 84-458-1176-2.
Véxase tamén
[editar | editar a fonte]Bibliografía
[editar | editar a fonte]- Stillwell R, Bierer BE (2002). "T cell signal transduction and the role of CD7 in costimulation.". Immunol. Res. 24 (1): 31–52. PMID 11485208. doi:10.1385/IR:24:1:31.
- Baker E, Sandrin MS, Garson OM; et al. (1990). "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization.". Immunogenetics 31 (5-6): 412–3. PMID 1695199. doi:10.1007/BF02115022.
- Schanberg LE, Fleenor DE, Kurtzberg J; et al. (1991). "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 603–7. PMC 50860. PMID 1703303. doi:10.1073/pnas.88.2.603.
- Yoshikawa K, Seto M, Ueda R; et al. (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7.". Immunogenetics 33 (5-6): 352–60. PMID 1711009. doi:10.1007/BF00216694.
- Ware RE, Scearce RM, Dietz MA; et al. (1990). "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.". J. Immunol. 143 (11): 3632–40. PMID 2479685.
- Osada S, Utsumi KR, Ueda R; et al. (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17.". Cytogenet. Cell Genet. 47 (1-2): 8–10. PMID 3258561. doi:10.1159/000132494.
- Aruffo A, Seed B (1988). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.". EMBO J. 6 (11): 3313–6. PMC 553785. PMID 3501369.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Lee DM, Schanberg LE, Fleenor DE; et al. (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters.". Immunogenetics 44 (2): 108–14. PMID 8662072.
- Bevec T, Stoka V, Pungercic G; et al. (1996). "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.". J. Exp. Med. 183 (4): 1331–8. PMC 2192513. PMID 8666891. doi:10.1084/jem.183.4.1331.
- Leta E, Hou Z, Lederman L, Jung LK (1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7.". Cell. Immunol. 173 (1): 15–21. PMID 8871597. doi:10.1006/cimm.1996.0247.
- Lee DM, Patel DD, Pendergast AM, Haynes BF (1997). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.". Int. Immunol. 8 (8): 1195–203. PMID 8918688. doi:10.1093/intimm/8.8.1195.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Slentz-Kesler KA, Hale LP, Kaufman RE (1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.". Genomics 47 (3): 327–40. PMID 9480746. doi:10.1006/geno.1997.5151.
- Steegmaier M, Yang B, Yoo JS; et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family.". J. Biol. Chem. 273 (51): 34171–9. PMID 9852078. doi:10.1074/jbc.273.51.34171.
- Pace KE, Lee C, Stewart PL, Baum LG (1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.". J. Immunol. 163 (7): 3801–11. PMID 10490978.
- Lyman SD, Escobar S, Rousseau AM; et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.". J. Biol. Chem. 275 (5): 3431–7. PMID 10652336. doi:10.1074/jbc.275.5.3431.
- Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054–60. PMID 11423532. doi:10.1074/jbc.M009913200.
- Rossi MI, Yokota T, Medina KL; et al. (2003). "B lymphopoiesis is active throughout human life, but there are developmental age-related changes.". Blood 101 (2): 576–84. PMID 12393702. doi:10.1182/blood-2002-03-0896.