Ver o código fonte de "Apolipoproteína C2"

{{Xene-proteína
|nome           = APOC2
|nomes          = APOC2, APO-CII, APOC-II, apolipoproteína C2
|imaxe           = Protein APOC2 PDB 1by6.png
|imaxe_tamaño    = 
|imaxe_pé       = 
|HGNCid           =609
|MGIid            =  88054
|símbolo          = APOC2
|símbolos_alt     = 
<!-- Datos xenéticos -->
|Xene              = APOC2
|Xene_tipo         = codificante de proteínas
|Cromosoma        = 19
|Brazo            = q
|Banda            = 13.32
|LocusSupplementaryData = 
<!-- Estrutura/función proteica -->
|Longo_proteína   = 
|Peso_molecular   = 
|Estrutura       = 
|Tipo             = 
|Funcións        = 
|Dominio          = 
|Motivo           = 
|Produtos_alt    = 
|Función         =
|Compoñente        =
|Proceso          =
<!-- Info adicional -->
|Taxon            = 
|Célula           = 
|Localización        = 
|Modificación     = 
|Ruta             = 
|Interaccións    = 
|Prop_biofisicas  = 
<!-- Datos encimáticos -->
|Act_catalítica   = 
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|Reg_encimática   = 
|Km               = 
|Vmax             = 
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|Acción           = 
|Agonista         = 
|Antagonista      = 
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|Enfermidade       = 
|Fármaco          = 
|Biotecnoloxía    = 
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|Accesión         = 
|ECnumber         = 
|ATC_prefix       = 
|ATC_suffix       = 
|ATC_supplemental = 
|CAS_number       = 
|CAS_supplemental = 
|DrugBank         =
|Homologene       = 47928
|IUPHAR           =
|OMIM             = 608083
|GeneAtlas_image1 =
|GeneAtlas_image2 =
|GeneAtlas_image3 =
|PDB              = 
|Varios_PDB       = {{PDB2|1SOH}} , {{PDB2|1BY6}} , {{PDB2|1I5J}} , {{PDB2|1O8T}}
|NCBI             =
|KEGG             =
|Orthologs =
<!-- Ortoloxía -->
|Hs_EntrezGene =344
|Hs_Ensembl =ENSG00000234906
|Hs_RefseqmRNA =NM_000483
|Hs_RefseqProtein =NP_000474
|Hs_GenLoc_db =hg19
|Hs_GenLoc_chr = 19
|Hs_GenLoc_start =44946035
|Hs_GenLoc_end =44949565
|Hs_Uniprot =P02655
|Mm_EntrezGene = 11813
|Mm_Ensembl = ENSMUSG00000002992
|Mm_RefseqmRNA = NM_001277944
|Mm_RefseqProtein = NP_001296728
|Mm_GenLoc_db = mm9
|Mm_GenLoc_chr = 7
|Mm_GenLoc_start = 19405504
|Mm_GenLoc_end = 19411866
|Mm_Uniprot = Q05020
<!-- Info relacionada -->
|Artigo         = 
|Publicación      = 
}}
{{Pfam box
| Símbolo = Apo-CII
| Nome = Apo-CII
| imaxe = 1i5j.jpg
| width = 270
| lenda = Estrutura de [[RMN]] da apolipoproteína C-II humana en presenza de [[SDS]]
| Pfam = PF05355
| Pfam_clan =  
| InterPro = IPR008019
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1by6
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
A '''apolipoproteína C2''' (tamén chamada '''apolipoproteína C-II''' ou '''ApoC-II''' entre outros nomes) é unha [[proteína]] que nos humanos está codificada no [[xene]] '''''APOC2''''' do [[cromosoma 19]].

A proteína codificada por este xene é segregada no plasma onde é un compoñente das [[lipoproteína de moi baixa densidade|lipoproteínas de moi baixa densidade]] e dos [[quilomicron]]s. Esta proteína activa o [[encima]] [[lipoproteína lipase]] nos [[capilar]]es,<ref name="pmid16314153">{{cite journal |vauthors=Kim SY, Park SM, Lee ST |title=Apolipoprotein C-II is a novel substrate for matrix metalloproteinases |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue=1 |pages=47–54 |year=2006 |pmid=16314153 |doi=10.1016/j.bbrc.2005.10.182}}</ref> o cal [[hidrólise|hidroliza]] [[triglicérido]]s e así proporciona [[ácido graxo|ácidos graxos]] libres para as células. [[Mutación]]s neste xene causan a [[deficiencia de apoproteína CII familiar|hiperlipoproteinemia tipo IB]], caracterizada por [[xantoma]]s, [[pancreatite]] e [[hepatoesplenomegalia]], pero non incrementan o risco de padecer [[aterosclerose]]. As probas de laboratorio mostraron nestes casos unha elevación dos niveis sanguíneos de triglicéridos, colesterol e quilomicrons.<ref name="entrez">{{cite web | title = Entrez Gene: APOC2 apolipoprotein C-II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=344}}</ref>

== Notas ==
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== Véxase tamén ==
=== Bibliografía ===
{{refempeza | 2}}
*{{cite journal  |vauthors=Jackson RL, Baker HN, Gilliam EB, Gotto AM |title=Primary structure of very low density apolipoprotein C-II of human plasma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=74 |issue= 5 |pages= 1942–5 |year= 1977 |pmid= 194244 |doi=10.1073/pnas.74.5.1942  | pmc=431048   }}
*{{cite journal  |vauthors=Lycksell PO, Ohman A, Bengtsson-Olivecrona G |title=Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. |journal=Eur. J. Biochem. |volume=205 |issue= 1 |pages= 223–31 |year= 1992 |pmid= 1555583 |doi=10.1111/j.1432-1033.1992.tb16772.x  |display-authors=etal }}
*{{cite journal  |vauthors=Hegele RA, Connelly PW, Maguire GF |title=An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia. |journal=Dis. Markers |volume=9 |issue= 2 |pages= 73–80 |year= 1992 |pmid= 1782747  |display-authors=etal}}
*{{cite journal  |vauthors=Crecchio C, Capurso A, Pepe G |title=Identification of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency (Apo CII-Bari). |journal=Biochem. Biophys. Res. Commun. |volume=168 |issue= 3 |pages= 1118–27 |year= 1990 |pmid= 1971748 |doi=10.1016/0006-291X(90)91145-I  }}
*{{cite journal  |vauthors=Bengtsson-Olivecrona G, Sletten K |title=Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing. |journal=Eur. J. Biochem. |volume=192 |issue= 2 |pages= 515–21 |year= 1990 |pmid= 2209608 |doi=10.1111/j.1432-1033.1990.tb19255.x  }}
*{{cite journal  |vauthors=Wei CF, Tsao YK, Robberson DL |title=The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes. |journal=J. Biol. Chem. |volume=260 |issue= 28 |pages= 15211–21 |year= 1986 |doi=10.1016/S0021-9258(18)95724-8 |pmid= 2415514 |display-authors=etal}}
*{{cite journal  |vauthors=Fojo SS, Lohse P, Parrott C |title=A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency. |journal=J. Clin. Invest. |volume=84 |issue= 4 |pages= 1215–9 |year= 1989 |pmid= 2477392 |doi=10.1172/JCI114287  | pmc=329780  |display-authors=etal}}
*{{cite journal |vauthors=Jackson CL, Bruns GA, Breslow JL |title=Isolation of cDNA and genomic clones for apolipoprotein C-II |journal=Meth. Enzymol. |volume=128 |pages=[https://archive.org/details/plasmalipoprotei0000unse/page/788 788–800] |year=1986 |pmid=3014272 |doi=10.1016/0076-6879(86)28106-9 |series=Methods in Enzymology |isbn=9780121820282  |url=https://archive.org/details/plasmalipoprotei0000unse/page/788 }}
*{{cite journal  |vauthors=Fojo SS, Law SW, Brewer HB |title=The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization |journal=FEBS Lett. |volume=213 |issue= 1 |pages= 221–6 |year= 1987 |pmid= 3030808 |doi=10.1016/0014-5793(87)81495-3   }}
*{{cite journal  |vauthors=Fojo SS, Stalenhoef AF, Marr K |title=A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II |journal=J. Biol. Chem. |volume=263 |issue= 34 |pages= 17913–6 |year= 1989 |doi=10.1016/S0021-9258(19)81302-9 |pmid= 3192518 |display-authors=etal}}
*{{cite journal  |vauthors=Fojo SS, Beisiegel U, Beil U |title=Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency |journal=J. Clin. Invest. |volume=82 |issue= 5 |pages= 1489–94 |year= 1988 |pmid= 3263393 |doi=10.1172/JCI113756  | pmc=442713  |display-authors=etal}}
*{{cite journal  |vauthors=Connelly PW, Maguire GF, Hofmann T, Little JA |title=Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 1 |pages= 270–3 |year= 1987 |pmid= 3467353 |doi=10.1073/pnas.84.1.270  | pmc=304185   }}
*{{cite journal  |vauthors=Fairwell T, Hospattankar AV, Brewer HB, Khan SA |title=Human plasma apolipoprotein C-II: total solid-phase synthesis and chemical and biological characterization |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 14 |pages= 4796–800 |year= 1987 |pmid= 3474626 |doi=10.1073/pnas.84.14.4796  | pmc=305192   }}
*{{cite journal  |vauthors=Fojo SS, Taam L, Fairwell T |title=Human preproapolipoprotein C-II. Analysis of major plasma isoforms |journal=J. Biol. Chem. |volume=261 |issue= 21 |pages= 9591–4 |year= 1986 |doi=10.1016/S0021-9258(18)67554-4 |pmid= 3525527 |display-authors=etal }}
*{{cite journal  |vauthors=Das HK, Jackson CL, Miller DA |title=The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron |journal=J. Biol. Chem. |volume=262 |issue= 10 |pages= 4787–93 |year= 1987 |doi=10.1016/S0021-9258(18)61264-5 |pmid= 3558370 |display-authors=etal }}
*{{cite journal  |vauthors=Connelly PW, Maguire GF, Little JA |title=Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease |journal=J. Clin. Invest. |volume=80 |issue= 6 |pages= 1597–606 |year= 1988 |pmid= 3680515 |doi=10.1172/JCI113246  | pmc=442428  }}
*{{cite journal  |vauthors=Baggio G, Manzato E, Gabelli C |title=Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 520–7 |year= 1986 |pmid= 3944267 |doi=10.1172/JCI112332  | pmc=423374  |display-authors=etal}}
*{{cite journal  |vauthors=Menzel HJ, Kane JP, Malloy MJ, Havel RJ |title=A variant primary structure of apolipoprotein C-II in individuals of African descent |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 595–601 |year= 1986 |pmid= 3944271 |doi=10.1172/JCI112342  | pmc=423392  }}
*{{cite journal  |vauthors=Sharpe CR, Sidoli A, Shelley CS |title=Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance |journal=Nucleic Acids Res. |volume=12 |issue= 9 |pages= 3917–32 |year= 1984 |pmid= 6328445 |doi=10.1093/nar/12.9.3917  | pmc=318799  |display-authors=etal}}
*{{cite journal  |vauthors=Jackson CL, Bruns GA, Breslow JL |title=Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 10 |pages= 2945–9 |year= 1984 |pmid= 6328478 |doi=10.1073/pnas.81.10.2945  | pmc=345197 }}
{{reftermina}}

=== Ligazóns externas ===
* {{UCSC gene info|APOC2}}

{{metabolismo das lipoproteínas}}
{{control de autoridades}}

[[Categoría:Apolipoproteínas]]