Receptor de C3a

C3AR1
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Nomenclatura	Outros nomes C3AR1, AZ3B, C3AR, HNFAG09, receptor do compoñente do complemento 3a 1, receptor co complemento C3a 1 ;
Identificadores; externos	OMIM: 605246 ; MGI: 1097680 ; HomoloGene: 2992 ; EBI: C3AR1 ; GeneCards: Xene C3AR1 ; UniProt: C3AR1 ;
Locus	Cr. 12 p13.31
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Padrón de expresión de ARNm
	Máis información
Ortólogos
Especies
Humano	Rato
Entrez
719	12267
Ensembl
Véxase HS	Véxase MM
UniProt
Q16581	O09047
RefSeq; (ARNm)
NM_004054	NM_009779
RefSeq; (proteína) NCBI
NP_001313404	NP_033909
Localización (UCSC)
Cr. 12:; 8.06 – 8.07 Mb	Cr. 6:; 122.82 – 122.83 Mb
PubMed (Busca)
719 ;	12267

O receptor de C3a (C3aR), tamén coñecido como receptor do compoñente do complemento 3a 1 (C3AR1) é unha proteína de tipo receptor acoplado á proteína G que intervén nas reaccións do sistema do complemento.^[1]^[2]

Este receptor únese ao compoñente do complemento 3a (C3a), aínda que hai probas limitadas de que este receptor tamén se une a C4a en mamíferos inferiores. Isto aínda está por probar que é certo en humanos.^[3] O receptor de C3a modula a inmunidade,^[4] artrite, obesidade inducida pola dieta^[5] e cancros.^[6]

Agonistas e antagonistas

Descubríronse agonistas^[7] e antagonistas^[8] potentes e selectivos para o C3aR.

Notas

↑ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (febreiro de 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1305 (1–2): 39–43. PMID 8605247. doi:10.1016/0167-4781(95)00209-x.
↑ Ali H, Panettieri RA (febreiro de 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research 6 (1): 19. PMC 551592. PMID 15723703. doi:10.1186/1465-9921-6-19.
↑ Klos A, Wende E, Wareham KJ, Monk PN (xaneiro de 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews 65 (1): 500–43. PMID 23383423. doi:10.1124/pr.111.005223.
↑ Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (outubro de 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation 13 (10): 2530–9. PMC 3809075. PMID 24033923. doi:10.1111/ajt.12405.
↑ Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (febreiro de 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal 27 (2): 822–31. PMID 23118029. doi:10.1096/fj.12-220582.
↑ Sayegh ET, Bloch O, Parsa AT (agosto de 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine 3 (4): 747–58. PMC 4303144. PMID 24711204. doi:10.1002/cam4.241.
↑ Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013). "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications 4: 2802. Bibcode:2013NatCo...4.2802R. PMID 24257095. doi:10.1038/ncomms3802.
↑ Reid RC, Yau MK, Singh R, Lim J, Fairlie DP (agosto de 2014). "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society 136 (34): 11914–7. PMID 25102224. doi:10.1021/ja506518t.

Véxase tamén

Outros artigos

Bibliografía

Sim RB, Laich A (outubro de 2000). "Serine proteases of the complement system". Biochemical Society Transactions 28 (5): 545–50. PMID 11044372. doi:10.1042/bst0280545.
Maruyama K, Sugano S (xaneiro de 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (febreiro de 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1305 (1–2): 39–43. PMID 8605247. doi:10.1016/0167-4781(95)00209-x.
Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C (agosto de 1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry 271 (34): 20231–4. PMID 8702752. doi:10.1074/jbc.271.34.20231.
Crass T, Raffetseder U, Martin U, Grove M, Klos A, Köhl J, Bautsch W (agosto de 1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells". European Journal of Immunology 26 (8): 1944–50. PMID 8765043. doi:10.1002/eji.1830260840.
Ames RS, Nuthulaganti P, Kumar C (outubro de 1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins". FEBS Letters 395 (2–3): 157–9. PMID 8898085. doi:10.1016/0014-5793(96)01018-6.
Martin U, Bock D, Arseniev L, Tornetta MA, Ames RS, Bautsch W, Köhl J, Ganser A, Klos A (xullo de 1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes". The Journal of Experimental Medicine 186 (2): 199–207. PMC 2198980. PMID 9221749. doi:10.1084/jem.186.2.199.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (outubro de 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Hollmann TJ, Haviland DL, Kildsgaard J, Watts K, Wetsel RA (febreiro de 1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene". Molecular Immunology 35 (3): 137–48. PMID 9694514. doi:10.1016/S0161-5890(98)00021-2.
Lienenklaus S, Ames RS, Tornetta MA, Sarau HM, Foley JJ, Crass T, Sohns B, Raffetseder U, Grove M, Hölzer A, Klos A, Köhl J, Bautsch W (setembro de 1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor". Journal of Immunology 161 (5): 2089–93. PMID 9725198. doi:10.4049/jimmunol.161.5.2089.
Davoust N, Jones J, Stahel PF, Ames RS, Barnum SR (maio de 1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells". Glia 26 (3): 201–11. PMID 10340761. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M.
Settmacher B, Bock D, Saad H, Gärtner S, Rheinheimer C, Köhl J, Bautsch W, Klos A (xuño de 1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a". Journal of Immunology 162 (12): 7409–16. PMID 10358194. doi:10.4049/jimmunol.162.12.7409.
Feild JA, Foley JJ, Testa TT, Nuthulaganti P, Ellis C, Sarau HM, Ames RS (outubro de 1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15". FEBS Letters 460 (1): 53–6. PMID 10571060. doi:10.1016/S0014-5793(99)01317-4.
Petering H, Köhl J, Weyergraf A, Dulkys Y, Kimmig D, Smolarski R, Kapp A, Elsner J (abril de 2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a". Journal of Immunology 164 (7): 3783–9. PMID 10725738. doi:10.4049/jimmunol.164.7.3783.
Drouin SM, Kildsgaard J, Haviland J, Zabner J, Jia HP, McCray PB, Tack BF, Wetsel RA (febreio de 2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma". Journal of Immunology 166 (3): 2025–32. PMID 11160252. doi:10.4049/jimmunol.166.3.2025.
Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD, Sulpizio AC, Hieble JP, McCafferty G, Ward KW, Adams JL, Bondinell WE, Underwood DC, Osborn RR, Badger AM, Sarau HM (maio de 2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models". Journal of Immunology 166 (10): 6341–8. PMID 11342658. doi:10.4049/jimmunol.166.10.6341.
Kirchhoff K, Weinmann O, Zwirner J, Begemann G, Götze O, Kapp A, Werfel T (xuño de 2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin". Immunology 103 (2): 210–7. PMC 1783227. PMID 11412308. doi:10.1046/j.1365-2567.2001.01197.x.
Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S, Glodek A, Honczarenko M, Spruce LA, Janowska-Wieczorek A, Lambris JD, Ratajczak MZ (maio de 2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1". Blood 101 (10): 3784–93. PMID 12511407. doi:10.1182/blood-2002-10-3233.

Ligazóns externas

International Union of Basic and Clinical Pharmacology (ed.). "Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. Arquivado dende o orixinal o 2016-03-03. Consultado o 2007-10-25.
C3AR1 protein, human Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA.
Localización no xenoma humano de C3AR1 e páxina con detalles sobre o xene C3AR1 no UCSC Genome Browser.

Este artigo sobre bioloxía é, polo de agora, só un bosquexo. Traballa nel para axudar a contribuír a que a Galipedia mellore e medre.
Existen igualmente outros artigos relacionados con este tema nos que tamén podes contribuír.

[pmid8605247-1] Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (febreiro de 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1305 (1–2): 39–43. PMID 8605247. doi:10.1016/0167-4781(95)00209-x.

[pmid15723703-2] Ali H, Panettieri RA (febreiro de 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research 6 (1): 19. PMC 551592. PMID 15723703. doi:10.1186/1465-9921-6-19.

[pmid=_23383423-3] Klos A, Wende E, Wareham KJ, Monk PN (xaneiro de 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews 65 (1): 500–43. PMID 23383423. doi:10.1124/pr.111.005223.

[4] Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (outubro de 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation 13 (10): 2530–9. PMC 3809075. PMID 24033923. doi:10.1111/ajt.12405.

[5] Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (febreiro de 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal 27 (2): 822–31. PMID 23118029. doi:10.1096/fj.12-220582.

[6] Sayegh ET, Bloch O, Parsa AT (agosto de 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine 3 (4): 747–58. PMC 4303144. PMID 24711204. doi:10.1002/cam4.241.

[7] Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013). "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications 4: 2802. Bibcode:2013NatCo...4.2802R. PMID 24257095. doi:10.1038/ncomms3802.

[8] Reid RC, Yau MK, Singh R, Lim J, Fairlie DP (agosto de 2014). "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society 136 (34): 11914–7. PMID 25102224. doi:10.1021/ja506518t.

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