CD61

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Integrina beta 3 (baseado en PDB 1jv2).

O CD61 (cluster de diferencaición 61) ou integrina beta-3 (β3) é unha proteína que se encontra na superficie celular das plaquetas ou trombocitos, que nos humanos está codificada no xene ITGB3 do cromosoma 17.[1] Funciona como molécula de adhesión celular.

Estrutura e función[editar | editar a fonte]

O produto proteico do ITGB3 é unha cadea beta beta 3 de integrina. As integrinas son proteínas integrais da superficie celular compostas por unha cadea alfa e unha beta. Unha determinada cadea pode combinarse con diversas moléculas orixinando distintos tipos de integrinas. A integrina beta 3 está combinada coa cadea alfa IIb nas plaquetas. As integrinas participan na adhesión celular e na sinalización celular mediada pola superficie celular.[2]

Na endometriose[editar | editar a fonte]

A expresión defectiva da subunidade β3 de integrina foi correlacionada coa endometriose, e propúxose como un posible marcador para esta doenza.[3]

Interaccións[editar | editar a fonte]

O CD61 interacciona con PTK2,[4][5] ITGB3BP,[6][7] TLN1[8][9] e CIB1.[10]

Notas[editar | editar a fonte]

  1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (August 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. DOI:10.1172/JCI113548. PMC 442653. PMID 2454952. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442653.
  2. "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3690.
  3. May, K. E.; Villar, J.; Kirtley, S.; Kennedy, S. H.; Becker, C. M. (2011). "Endometrial alterations in endometriosis: A systematic review of putative biomarkers". Human Reproduction Update 17 (5): 637–653. doi:10.1093/humupd/dmr013. PMID 21672902.
  4. Eliceiri, Brian P; Puente Xose S, Hood John D, Stupack Dwayne G, Schlaepfer David D, Huang Xiaozhu Z, Sheppard Dean, Cheresh David A (April 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. (United States) 157 (1): 149–60. DOI:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173263.
  5. Chung, J; Gao A G, Frazier W A (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. (UNITED STATES) 272 (23): 14740–6. DOI:10.1074/jbc.272.23.14740. ISSN 0021-9258. PMID 9169439.
  6. Fujimoto, Tetsuro-Takahiro; Katsutani Shinya, Shimomura Takeshi, Fujimura Kingo (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. (United States) 105 (1): 63–70. DOI:10.1016/S0049-3848(01)00405-4. ISSN 0049-3848. PMID 11864709.
  7. Shattil, S J; O'Toole T, Eigenthaler M, Thon V, Williams M, Babior B M, Ginsberg M H (November 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J. Cell Biol. (UNITED STATES) 131 (3): 807–16. DOI:10.1083/jcb.131.3.807. ISSN 0021-9525. PMC 2120613. PMID 7593198. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120613.
  8. Patil, S; Jedsadayanmata A, Wencel-Drake J D, Wang W, Knezevic I, Lam S C (October 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. (UNITED STATES) 274 (40): 28575–83. DOI:10.1074/jbc.274.40.28575. ISSN 0021-9258. PMID 10497223.
  9. Calderwood, David A; Yan Boxu, de Pereda Jose M, Alvarez Begoña García, Fujioka Yosuke, Liddington Robert C, Ginsberg Mark H (June 2002). "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. (United States) 277 (24): 21749–58. DOI:10.1074/jbc.M111996200. ISSN 0021-9258. PMID 11932255.
  10. Naik, U P; Patel P M, Parise L V (February 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J. Biol. Chem. (UNITED STATES) 272 (8): 4651–4. DOI:10.1074/jbc.272.8.4651. ISSN 0021-9258. PMID 9030514.

Véxase tamén[editar | editar a fonte]

Outros artigos[editar | editar a fonte]

Outras lecturas[editar | editar a fonte]

  • Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.
  • Bennett JS (2001). "Platelet-fibrinogen interactions.". Ann. N. Y. Acad. Sci. 936: 340–54. DOI:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491.
  • Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.
  • Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. DOI:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
  • Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.". Italian heart journal : official journal of the Italian Federation of Cardiology 4 (1): 17–22. PMID 12690916.
  • Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.". Thromb. Res. 112 (4): 209–16. DOI:10.1016/j.thromres.2003.11.010. PMID 14987913.
  • Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.". Curr. Pharm. Des. 10 (14): 1567–76. DOI:10.2174/1381612043384682. PMID 15134555.
  • Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730.
  • Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752–62. DOI:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.
  • Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3.". J. Clin. Invest. 115 (12): 3363–9. DOI:10.1172/JCI26989. PMC 1297263. PMID 16322781. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1297263.

Ligazóns externas[editar | editar a fonte]